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Antihistaminic Pharmaceutical Raw Materials CAS 79307-93-0 Azelastine Hydrochloride
- May 08, 2018 -

Antihistaminic Pharmaceutical Raw Materials CAS 79307-93-0 Azelastine Hydrochloride Basic Info

  • Model NO.: 79307-93-0

  • Customized: Non-Customized

  • Suitable for: Elderly, Children, Adult

  • Microspheres Purity: >99%

  • M.W.: 418.36

  • Appearance: White Crystalline Solid

  • Microspheres Transport Package: 1kg/Foil Bag

  • Origin: Made in China

  • Powder: Yes

  • Certification: GMP, ISO 9001, USP, BP, SGS, Kosher

  • Microspheres State: Solid

  • M.F.: C22h25cl2n3o

  • CAS: 79307-93-0

  • Microspheres Specification: 25kg/drum

  • HS Code: 3001200020

Antihistaminic Pharmaceutical Raw Materials CAS 79307-93-0 Azelastine Hydrochloride Product Description

Product Name: Azelastine hydrochloride 
Synonyms: a5610;azeptin;e-0659;w-2979m;AZELASTINE HCL;AZELASTINE HYDROCHLORIDE;4-[(4-chlorophenyl)methyl]-2-(1-methylazepan-4-yl)-phthalazin-1-one hydrochloride;4-[(4-Chlorophenyl)methyl]-2-(hexahydro-1-methyl-1H-azepin-4-yl)-1(2H)-phthalazinone Hydrochloride 
CAS: 79307-93-0 
MF: C22H25Cl2N3O 
MW: 418.36
Product Categories: Antihistaminic;Intermediates & Fine Chemicals;Pharmaceuticals;Histamine receptor;Astelin
Melting point  225--229oC
Storage temp.  -20°C Freezer 
Stability: Incompatible with strong oxidizing agents. 
Chemical Properties White Crystalline Powder 
Usage Orally active H1-hystamine receptor antagonist. Antihistaminic .

Azelastine hydrochloride Application

Azelastine hydrochloride is a H1 histamine receptor antagonist and NF-kB activator. Azelastine hydrochloride has been used in a study to investigate the potential of polymeric microspheres for treatment of allergic conjunctivitis.

Azelastine hydrochloride Description

Astelin (azelastine hydrochloride) Nasal Spray, 137 micrograms (mcg), is an antihistamine formulated as a metered-spray solution for intranasal administration. Azelastine hydrochloride occurs as a white, almost odorless, crystalline powder with a bitter taste. It has a molecular weight of 418.37. It is sparingly soluble in water, methanol, and propylene glycol and slightly soluble in ethanol, octanol, and glycerine. It has a melting point of about 225°C and the pH of a saturated solution is between 5.0 and 5.4. Its chemical name is (±)-1-(2H)-phthalazinone,4-[(4chlorophenyl) methyl]-2-(hexahydro-1-methyl-1H-azepin-4-yl)-, monohydrochloride.

Astelin Nasal Spray contains 0.1% azelastine hydrochloride in an aqueous solution at pH 6.8 ± 0.3. It also contains benzalkonium chloride (125 mcg/mL), edetate disodium, hypromellose, citric acid, dibasic sodium phosphate, sodium chloride, and purified water.

After priming [see DOSAGE AND ADMINISTRATION], each metered spray delivers a 0.137 mL mean volume containing 137 mcg of azelastine hydrochloride (equivalent to 125 mcg of azelastine base). The bottle can deliver 200 metered sprays.

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